Principle of 2-amino-5-nitrothiazole storage conditions

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2-amino-5-nitrothiazole storage conditions https://www.clentpharma.com/2-Amino-5-nitrothiazole.html

Butyl-lithium is easy to react with organic compounds containing active C-H bonds, the so-called hydrogen-lithium exchange reaction, to produce new organolli-lithium compounds. Alkyl lithium can add carbonyl compounds, replace active hydrogen, and halogen-lithium exchange reaction, its reaction performance is more extensive and diversified than the general Grignard reagent.

Add 120 ml of n-hexane solution, 4.8 g (0.7 mol) of lithium wire, and add 29.6 g (0.32mmol) of n-butane chloride into a three-way flask equipped with a drip funnel, thermometer and condensing tube under nitrogen protection. Slowly heat up and keep boiling steadily. After about 1 hour of drip adding, continue reflux reaction for 1.5 hours, cool down, and let stand overnight. Filter under nitrogen protection, and the filtrate is stored by flushing nitrogen.

Methyl lithium and methyl cupric form dimethyl lithium cupric in ether solution, which is an extremely important methylation reagent. It can carry out methyl substitution of halogen for unsaturated or aromatic halogen compounds. Lithium reacts with trimethylchlorosilane to form an important silication reagent that has a variety of uses for protecting enols or hydroxyl groups.

2-amino-5-nitrothiazole storage conditions can be prepared from the reaction of chloroprene with lithium metal in pentane or other liquid alkanes. Methyl lithium, lithium phenyl, etc., can be prepared from the corresponding halogenated hydrocarbons, ready to use, its activity is similar to Glia reagent. Methyl lithium is a tetramer in solution, which often requires the addition of N,N,N ',N '-tetramethylenediamine for depolymerization activation.

2-amino-5-nitrothiazole storage conditions https://www.clentpharma.com/2-Amino-5-nitrothiazole.html

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